Treatment Of The Human Papilloma Virus Infection Part 2

A series of researchers as the best way of treatment of genital warts recognize surgical excision of all visible lesions with the subsequent local introduction. The therapeutic effect from application is absent, if disease lasts more than one year, and also at an immunodeficiency.

Now there are not so many agents which can be used after application of destructive methods. In particular, there was now a preparation for local application in the field of the centers of a lesion after destructive influence.

Specific antiviral therapy

Now there are no the preparations that has specific effect on HPV. The known agents suppressing replication of a virus of simple herpes (an acyclovir) have appeared to be noneffective at treatment of genital HPV-INFECTIONS.

Theoretically bacterination represents an ideal method of treatment and preventive maintenance of genital warts.

The effect from use of monotherapy all the same is insufficiently studied and not so high, besides, it is necessary to take into consideration high cost of such treatment. In this connection the given method hasn’t received a wide circulation in practice.

Izonoprine. Recent years steadfast attention of immunologists was attached to the new immunomodulation izonoprine. The preparation can be applied in the form of tablets or a solution for parenteral injection. Active substance in this complex, apparently, is Inosinum, and amino alcohol salt that stimulates its penetration through a membrane of lymphocytes and other cells.

It possesses powerful and wide immunomodulation action. The numerous data and the extensive literature testify that in vitro preparation essentially strengthens proliferation of T-lymphocytes induced by mitogens or specific antigens, and also a differentiation of pre-T-lymphocytes in more mature of T-lymphocytes, accompanied by occurrence on their surface of corresponding antigens. It also stimulates the proliferation of V-lymphocytes induced by a mitogen.

Various schemes of treatment with application of izonoprine depending on the sizes of condylomas, their localization and malignancy degree are accepted.

The scheme 1: fine treatment, plural peaked condylomas with low degree of a malignancy. The preparation is accepted. by three times a day within 14–28 days.

The scheme 2: treatment of plural condylomas with separate large condylomas or a flat condyloma of a neck of a uterus.

Among applied chemical preparations that has destructive effect, it is possible to allocate nitric acid, and also the combined acid preparation — solcoderm. It is applied at 80-90 %-s’ concentration and causes formation of a local coagulative necrosis. Similar action renders a nitric acid solution. Owing to the cheapness and availability both methods enough widespread and to this day. Acids are effective for treatment of condylomas of a vulva, a coronal sulcus, a balanus, especially when other treatment is contraindicative.

Cauterizations spend once a week within 5-6 weeks. Efficiency of application makes approximately 70-80 %. Local reaction in a kind moistening and ulcerations can develop in certain cases.

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